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Published Research on PPCM and Related Articles

Women's Interest in Vaginal Microbicides, J. Darroch; J. Frost, Family Planning Perspectives, Vol. 31, No. 1 (Jan. - Feb., 1999), 16-23. 

Topical microbicides for the prevention of genital herpes infection, M. Keller, A. Tuyama, M.J. Carlucci, B. Herold, Journal of American Chemotherapy (2005) 55, 420-423. 

Mandelic Acid Condensation Polymer: Novel Candidate Microbicide for Prevention of Human Immunodeficiency Virus and Herpes Simplex Virus Entry, B.C. Herold, I. Scordi-Bello, N. Cheshenko, D. Marcellino, F. Francois, R. Morin, V.Mas Casullo, R.A. Anderson, C. Chany II, D.P. Waller, L.J.D. Zaneveld, M.E. Klotman, Journal of Virology, Nov 2002, p. 11236-11244. 

Use of mandelic acid condensation polymer (SAMMA), a new antimicrobial contraceptive agent, for vaginal prophylaxis, Lourens J.D. Zaneveld, D.V.M., Ph.D., Robert A Anderson, Ph.D., Xiao-Hui Diao, M.S., Donald P. Waller, Ph.D., Calvin Chany II, Ph.D., Kenneth Feathergill, M.S., Gustavo Doncel, M.D., Ph.D., Morris D. Cooper, Ph.D., Betsy Herold, M.D., Fertility and Sterility, Vol. 78, No. 5, November 2002.

Candidate Topical Microbicides Bind Herpes Simplex Virus Glycoprotein B and Prevent Viral Entry and Cell-to-Cell Spread, Natalia Cheshenko, Marla J. Keller, Veronica MasCasullo, Gary A. Jarvis, Hui Cheng, Minnie John, Jin-Hua Li, Kathleen Hogarty, Robert A. Anderson, Donald P. Waller, Lourens J.D. Zaneveld, Albert T. Profy, Mary E. Klotman, Betsy C. Herold, Antimicrobial Agents and Chemotherapy, June 2004, p. 2025-2036.

Rigorous Pre-clinical Ealuation of Topical Microbicides to Prevent Transmission of Human Immunodeficiency Virus, Keller M, Klotman M,Herold B "Journal of Antimicrobial Chemotherapy (2003) 51, 1099-1102

SAMMA Induces Premature Huan Acrosomal Loss by Ca2+ Signaling Dysregulation, Anderson RA, Feathergill K, Waller D, Zaneveld L, Journal of Andrology 2006 27:568-577

SAMMA, a mandelic cid condensation polymer, inhibits dendritic cell-mediated HIV transmission, Chang T, Teleshova N, Rapista A, Paluch M, Anderson RA, Waller , Zaneveld L, Granelli-Piperno A, Klotman M, FEBS Letter 2007 581:4596-4602

Candidate Microbicide PPCM Blocks Human Immunodeficiency Virus Type 1 Infection in Cell an Tissue Cultures and Prevents Genital Herpes in a Murine Model, Mesquita P, Wilson S, Manlow P, Fishetti L, Keller M, Herold BC, Shattock R, Journal of Virology  2008 82:6576-6584

Nitric Oxide-dependent Human Acrosomal Loss Induced by PPCM (SAMMA) and by Nitric Oxide Donors Occurs by Independent Pathways: Basis for Synthesis of an Improved Contraceptive Microbicide, Anderson R, Feathergill K, et al, Journal of Andology  2009 30(2):158-82